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  • Putting the “More” in Morphology: Part 2

    Wednesday, April 10, 2013
    Technical Article
    Barbara Foster
    Part 1 of this article discussed the impact of multiplexing morphological methods, multiparametric techniques, and supervised machine-learning to answer the question "what" is there, as well as "where... read more

  • Detection of siRNA-Mediated Gene Modulation Using RNA Detection Probes

    Monday, May 20, 2013
    Application Note
    Don Weldon Grace Johnston
    To study the function of genes and biological pathways, researchers often use techniques such as RNA interference (RNAi) to modify gene expression. In RNAi experiments, it is important to determine ... read more

  • Automated Refractive Index Calculations for Particle Size Analysis Using Laser Diffraction

    Monday, June 03, 2013
    Technical Article
    Mark Bumiller
    Laser diffraction has been the most common particle size analysis technique for many years. The technique is fast, flexible, and easy to use for a wide variety of sample types. read more

  • Fast, Efficient Antibody Biotinylation for Cleaner Immunodetection Assays

    Friday, June 07, 2013
    Application Note
    Amedeo Cappione Masaharu Mabuchi David Briggs Timothy Nadler
    Many protein detection methods, including Western blotting, flow cytometry, ELISA, and immunohistochemistry, require the use of target-specific probes, such as antibodies, that are detected via two-... read more

  • Understanding the Links Between Rheology and Particle Parameters

    Wednesday, November 01, 2006
    Technical Article
    Steve Carrington Adrian Hill
    The rheology of a suspension or dispersion relates directly to many parameters of commercial interest. read more

  • Sizing Particles

    Tuesday, November 01, 2005
    Technical Article
    Michael Levin
    Many methods and numerous instruments are available from recognized vendors to measure particle size. read more

  • High-Throughput Screening of Multiple Protein Complexes

    Thursday, July 04, 2013
    Application Note
    Imre Berger Maxime Chaillet Frederic Garzoni Sinyee Yau-Rose Barney Zoro
    Key protein complexes are fundamental to a wide range of cellular processes and key metabolic pathways within the body. Their dysfunction is associated with a range of disease pathologies such as ... read more

  • Measurement of IL-6 RNA Levels in Live Cells

    Wednesday, July 10, 2013
    Application Note
    Shobana Vaidyanathan
    Infections and tissue damage lead to acute inflammatory responses, orchestrated by the release of cytokines from macrophages and mast cells, as well as endothelium and tumor cells. Tumor necrosis ... read more

  • Impact of New Pipetting Techniques on Safety in the Laboratory

    Monday, September 02, 2013
    Application Note
    Bobby Chavli Annette Summers Mary Napier
    According to the Occupational Safety and Health Administration (OSHA), on average, it takes between 18 and 36 months to develop and implement a new regulation, trailing the pace of science. As a ... read more

  • Characterizing Nanoparticles in Liquids: Protein Aggregation Studies

    Monday, September 16, 2013
    Application Note
    Pauline Carnell Sarah Newell
    Many patients’ lives have been improved with the use of monoclonal antibodies and recombinant proteins since their commercialization about 30 years ago. Work in the field of therapeutic proteins ... read more

  • Multiparameter Pluripotency Analysis Using Magnetic Bead Assays

    Wednesday, August 28, 2013
    Application Note
    Nikolai Stankiewicz Thomas Siegl Frederick Wiese
    For the application of induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) to regenerative medicine and drug discovery research, it is crucial to characterize the identity ... read more

  • Single-Cell RNA Detection to Identify Cell Subpopulations in Heterogeneous Mixtures

    Tuesday, March 25, 2014
    Application Note
    Don Weldon Victor Koong Alex Ko Yuko Williams Laura White
    Traditional RNA detection methods, which analyze RNA levels in lysed, permeabilized, or fixed cell samples, make it challenging to understand the role of one gene in the context of a tissue, organ, or... read more

  • Product Intelligence: Particle Sizing Systems: Key to QC and Product Testing

    Friday, September 20, 2013
    Technical Article
    Caitlin Smith
    A host of particle sizing systems is available to measure a wide array of particle sizes. Fundamental checkpoints to consider before selecting a particle size analyzer include the range of particle ... read more

  • DNA in Forensics

    Wednesday, August 28, 2013
    Technical Article
    Robert L. Stevenson, Ph.D.
    The proliferation of forensic DNA testing and databases by state and local jurisdictions was recently reported by Joseph Goldstein in The New York Times. For years, the FBI’s combined indexing system ... read more

  • The Story of MALS

    Saturday, October 05, 2013
    Technical Article
    Philip J. Wyatt
    The concept of measuring light scattered from a solution at each of a plurality of angles simultaneously began in late 1976 in a very unlikely application. At that time, scientists from Science ... read more

  • Improved Long-Term Culture Using A Microfluidic Platform

    Monday, October 07, 2013
    Application Note
    Alex Mok Paul Hung Cindy Chen Sónia Gil Kathleen Ongena
    Precise and biologically relevant in vitro studies require the ability to analyze cell responses to perturbations over time. In order to achieve successful long-term cell culture and imaging, however,... read more

  • Use of Integrated Data Analysis to Gain an Advantage in Biomarker Discovery and Personalized ...

    Saturday, October 01, 2011
    Technical Article
    Jens Hoefkens
    The genomic revolution of the last two decades has provided pharmaceutical companies with an almost overwhelming number of potential drug targets. read more

  • Evolution of Wyatt Technology Corp.

    Tuesday, May 06, 2014
    Application Note
    Robert L. Stevenson, Ph.D.
    Over the last 56 years, Wyatt Technology Corp. (WTC), including the adaptation of innovations from its progenitor, Science Spectrum, has earned a reputation for developing and marketing instruments ... read more

  • Micro RNA Profiling with a Multiplexed Assay

    Monday, March 03, 2014
    Application Note
    Mark Santos
    From the discovery of new miRNAs to clarifying their biological roles and utility as biomarkers, micro RNA (miRNA)-based research is undergoing a period of change. Rigorous methods are therefore ... read more

  • What Does Your Particle Size Data Mean?

    Thursday, February 19, 2015
    Application Note
    Paul Kippax Deborah Huck-Jones
    Laser diffraction is a mature technology with extensive capabilities. Highly automated and easy to use, modern laser diffraction systems efficiently meet the requirements for particle size data ... read more
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